Beschreibung:
Multiple motile cilia are present on specialized epithelial cells lining the airways, reproductive ducts, and brain ventricles. Cilia beating contributes to fluid movement and particle transport along the multiciliated surfaces. Dysfunction of motile cilia leads to ciliopathies such as primary ciliary dyskinesia, which is mainly characterized by respiratory infections, infertility, and - in rare cases - hydrocephalus. Due to the diverse vital functions of motile cilia, multiciliogenesis must be tightly controlled at both the transcriptional and post-transcriptional level. We recently identi...