Comparison of 68Ga-DOTATOC biodistribution in patients with and without spleenectomy

Medientyp: E-Artikel
Titel: Comparison of 68Ga-DOTATOC biodistribution in patients with and without spleenectomy
Beteiligte: Kratochwil, Clemens [Verfasser:in]; Mavriopoulou, Eleni [Verfasser:in]; Rath, Daniel [Verfasser:in]; Afshar-Oromieh, Ali [Verfasser:in]; Haufe, Sabine [Verfasser:in]; Haberkorn, Uwe [Verfasser:in]; Giesel, Frederik L. [Verfasser:in]
Erschienen: March 2015
Erschienen in: The quarterly journal of nuclear medicine and molecular imaging ; 59(2015), 1, Seite 116-120
Sprache: Englisch
Schlagwörter: Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Neuroendocrine Tumors ; Octreotide ; Organometallic Compounds ; Organ Specificity ; Pancreatic Neoplasms ; Positron-Emission Tomography ; Radiopharmaceuticals ; Receptors, Somatostatin ; Reproducibility of Results ; Sensitivity and Specificity ; Splenectomy ; Tissue Distribution ; Whole Body Imaging
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Beschreibung: Ga-68 labeled somatostatin analogues such as 68Ga-DOTA0-Phe1-Tyr3-octrotide (DOTATOC) as PET tracers, have significantly improved the imaging of somatostatin receptors (SSTRs) expressing tumors. Due to unspecific parenchymal binding and the expression of SSTRs on leukocytes in the spleen this is the organ with the highest non-tumor uptake of DOTATOC. Therefore, we investigated the potential changes of normal tissue distribution and tumor concentration in patients with neuroendocrine tumors (NETs) with or without spleenectomy.
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