Adjuvant Therapy for Breast Cancer

Medientyp: E-Book

Titel: Adjuvant Therapy for Breast Cancer

Enthält: Adjuvant Therapy for Breast Cancer; Cancer Treatment and Research; Acknowledgments; Contents; Contributors; Introduction; Part 1: Basics; History of Adjuvant Therapy; The Guiding Principles of Adjuvant Therapy; Trials with Endocrine Therapy; Trials of Chemoendocrine Therapy; Trials with Chemotherapy; Concluding Remarks; References; Prognostic and Predictive Factors; Prognostic Factors; Age; Tumor Size; Axillary Nodes; Tumor Grade; HER2/neu Status; Peritumoral Vascular Invasion; Others; Predictive Factors; Predictive Markers for Adjuvant Hormonal Therapy
Predictive Markers for Adjuvant ChemotherapyHER-2 as a Predictive Marker; Topoisomerase II Alpha (Topo IIalpha); Markers Predicting the Activity of Taxane-Based Regimens; Markers Predicting the Activity of Anti-HER-2 Therapies; Conclusions; References; New Perspectives for Therapy Choice; Introduction; ''Omics'' in Cancer Diagnosis and Prognosis; Gene Expression Profiling: Genomics and Transcriptomics; Protein Profiling: Proteomics; Profiling of Metabolic Endproducts: Metabolomics; Nano-Particles in Diagnosis and Therapy; Perspectives; References; Pathology Role in Adjuvant Setting
IntroductionExamination of Pathology Specimens; Core Needle Biopsy - Preoperative Diagnosis; Surgical Specimens; Frozen Sections; Tissue Banks; Tumor Classification; Histopathologic Prognostic Factors; Tumor and Axillary Lymph Node Staging; Lymph and Blood Vessel Invasion; Tumor Size; Tumor Grading; Immunhistochemical Assays; Steroid Hormone Receptors; HER-2/neu; HER-2 Immunohistochemistry; HER-2 FISH; Interpretation and Scoring; Immunohistochemistry; FISH; Which Score to Be Used?; Future Aspects; Microarray Technology; References
Guidelines, Consensus Conferences and Overviews (Meta-analysis)Introduction; Meta-analysis or Overviews; Consensus Meetings and Documents; Clinical Practice Guidelines; Summary; References; Statistical Issues and Challenges; Learning from the Past; Planning for the Future; References; Part 2: Treatments; Multidisciplinary Care: Optimising Team Performance; Introduction; Sharing Goals and Strategies; Effective Team Meetings; Troubleshooting; Development and Coaching; Inspirational Leadership; Strengthening Commitment; Managing Conflict and Poor Performance; Preventing Burnout
Improving Communication with PatientsConclusions; References; Preoperative Chemo- and Endocrine Therapy; Primary Systemic Therapy: Rationale and State of the Art; The Role pf pCR; Anthracyclines and Taxanes: Which is the Gold Standard?; Primary Treatment of Endocrine Responsive Tumours; Open Issues; Identifying Powerful Predictors of Response; Beyond pCR; Integrating Targeted Agents; Conclusions; References; Adjuvant Chemotherapy; Anthracyclines in Adjuvant Therapy; Duration of treatment; Dose Intensity
Randomized Studies of High-Dose Adjuvant Chemotherapy with Hematopoietic Stem Cell Transplantation

Beteiligte: Castiglione, Monica [VerfasserIn]; Piccart-Gebhart, Martine J. [Sonstige Person, Familie und Körperschaft]

Erschienen: Boston, MA: Springer-Verlag US, 2009

Umfang: Online-Ressource (digital)

Sprache: Englisch

DOI: 10.1007/978-0-387-75115-3

ISBN: 9780387751153; 9780387751146

Identifikator:

Schlagwörter: Medicine ; Oncology ; Cancer Surgery ; Medicine & Public Health ; Breast Neoplasms therapy ; Adjuvants, Pharmaceutic ; Chemotherapy, Adjuvant ; Radiotherapy, Adjuvant

Entstehung:

Anmerkungen: Includes bibliographical references and index

Beschreibung: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable. 'The adjuvant treatment of breast cancer has become standard of care. A spectrum of biologic and prognostic factors are considered before a therapeutic strategy is implemented. In this text leading investigators in the field discuss current management and critical investigative issues.' Steven T. Rosen, M.D. Series Editor

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