Alcohol, Tobacco and Cancer

Medientyp: E-Book

Titel: Alcohol, Tobacco and Cancer

Enthält: ""Cover""; ""Contents""; ""Preface""; ""General Cancer""; ""General Mechanisms of Cancer""; ""Abstract""; ""Environmental Causes""; ""Inherited Susceptibility to Cancer""; ""Unifying Themes in Carcinogenesis""; ""Methylation and Carcinogenesis""; ""De Novo Methylation of CPG Islands""; ""Hypomethylation""; ""DNA Methylation and Mutation""; ""Conclusion""; ""References""; ""Alcohol and Cancer""; ""Epidemiology of Alcohol-Associated Cancers""; ""Abstract""; ""United States Trends in Cancer Incidence""; ""Oral and Pharyngeal Cancer""; ""Squamous Cell Esophageal Cancer""; ""Larynx Cancer""
""Liver Cancer""""Colorectal Cancer""; ""Breast Cancer""; ""Pancreas Cancer""; ""United States Trends in Alcohol and Tobacco Use""; ""Alcohol Measurement Issues in Epidemiologic Studies""; ""Alcohol-Associated Cancers: Case-Control and Cohort Studies""; ""Upper Aerodigestive Tract Cancers""; ""Oral and Pharyngeal Cancer""; ""Squamous Cell Esophageal Cancer""; ""Larynx Cancer""; ""Other Alcohol-Associated Cancers""; ""Liver Cancer""; ""Colorectal Cancer""; ""Breast Cancer""; ""Pancreas Cancer""; ""Conclusions""; ""Acknowledgemants""; ""References""; ""Alcohol Metabolism,Tobacco and Cancer""
""Abstract""""Alcohol Metabolism""; ""Genetic Variations in Ethanol Metabolism: Role of Acetaldehyde""; ""Formation of ROS and Decrease in Antioxidants""; ""Adduct Formation, DNA Damage, and Cancer""; ""Acetaldehyde Adducts""; ""Alcohol Adducts""; ""Adducts Associated with the Generation of ROS""; ""Tobacco, Smoking, and Cancer""; ""Alcohol, DNA Methylation, and Cancer Susceptibility""; ""References""; ""Interaction of Alcohol and Tobacco in Upper Aerodigestive Tract and Stomach Cancer""; ""Abstract""; ""Epidemiological Interactions""
""Independent and Synergistic Effects of Alcohol and Tobacco on Cancer Risk""""Effect of Gene Polymorhism on Cancer Risk""; ""Aldehyde Dehydrogenase Deficiency""; ""High Active Alcohol Dehydrogenases""; ""Acetaldehyde as a Carcinogen""; ""Biochemical Interactions Mediated by Microbes""; ""Accumulation of Acetaldehyde in the Saliva after Alcohol Drinking""; ""Microbial Acetaldehyde Production in the Saliva""; ""Alcoholic fermentation""; ""Acute Effects of Smoking on Salivary Acetaldehyde""; ""Effect of Chronic Smoking on Microbial Acetaldehyde Production in the Saliva""
""Effect of Heavy Alcohol Consumption on Microbial Acetaldehyde Production in the Saliva""""Effect of Poor Oral Hygiene on Microbial Acetaldehyde Production in the Saliva""; ""Biochemical Interactions Mediated by Genes""; ""ALDH2-Deficient Asians""; ""High ADH-Activity Caucasians""; ""Acetaldehyde in the Stomach""; ""Possible Future Preventive Actions""; ""References""; ""Alcohol and Cancer of the Large Intestine""; ""Abstract""; ""Epidemiology""; ""Animal Experiments""; ""Mechanisms by Which Alcohol Stimulates Colorectal Carcinogenesis""; ""Acetaldehyde""; ""Acetaldehyde Toxicity""
""Acetaldehyde Metabolism in Colorectal Mucosa""

Beteiligte: Cho, Chi Hin [Herausgeber:in]

Erschienen: Basel: S. Karger, 2006

Umfang: Online-Ressource (VIII + 312)

Sprache: Englisch

ISBN: 9783318013382

RVK-Notation: XH 5000 : Allgemeines

Schlagwörter: Nicotin > Carcinogenität
Alkohol > Carcinogenität

Entstehung:

Anmerkungen: A comprehensive review of carcinogenic mechanisms and prevention strategies

Beschreibung: Excessive alcohol consumption and smoking are among the major risk factors for cancer. Simultaneous indulgence further increases the risk for especially cancer of the upper aerodigestive tract due to the interaction of several metabolic and genetic factors.The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in producing liver cancer are addressed.The second part is dedicated to the role of tobacco in lung and digestive tract cancers and to their prevention, highlighting the role of phytochemicals. More specifically, the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive properties of nicotine which are involved in the development of cancer, and the possible use of nicotine vaccine in the prevention of mortality associated with tobacco, are discussed. Highlighting general mechanisms leading to cancer and providing the latest information on the underlying mechanisms whereby alcohol consumption and tobacco use initiate and/or promote carcinogenesis, this book is a valuable source of information for all those interested in the topic.

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