Berg, Robert Markus
[Verfasser:in]
;
Wallaschofski, Henri
[Akademische:r Betreuer:in];
Schober, Hans-Christof
[Akademische:r Betreuer:in]Universität Greifswald
Die Assoziation zwischen Fettgewebe und Knochensteifigkeit
Hochschulschrift:
Dissertation, Universitätsmedizin der Universität Greifswald, 2019
Anmerkungen:
Literaturverzeichnis: Seite 26-29
Text deutsch, Anhang englisch
Beschreibung:
Body Mass Index, Fersenbein, Fettgewebe, Osteoporose, Knochensteifigkeit, Quantitativer Ultraschall, Steifigkeitsindex, Viszeralfett
Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20–79 years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general ...