Beschreibung:
Myelin is a lipid rich membrane produced by oligodendrocytes in the central nervous system. During development, oligodendrocyte precursor cells find their target axons and start to wrap their processes around axons, thereby creating a multilayered insulating sheath. Those sheaths are regularly distributed along the axon with small, intersecting gaps called Nodes of Ranvier. This insulation results in increase in signaling conduction velocity. Furthermore, recent publications suggest that myelin is a dynamic structure that can adapt to environmental changes. I investigated the epigenetic con...