Beschreibung:
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of less than 8 %. Hallmarks of pancreatic cancer are extensive desmoplasia and strong resistance to standard chemotherapeutic agents, e.g. gemcitabine. In this context, impaired drug delivery and drug metabolism pathways might play a crucial role in mediating this pronounced chemoresistance. In this study, I investigated tumor cell intrinsic and extrinsic mechanisms of chemotherapeutic resistance in PDAC. Pharmacokinetic characteristics of gemcitabine (dFdC) were analyzed in the widely used LSL-Kras...