Beschreibung:
In the human central nervous system, astrocytes vastly outnumber neurons and regulate a host of physiological processes critical to its function. Astrocytes form a functional syncytium tiling the brain with minimal overlap between individual cells. This anatomical organization implies that a balanced numbers of neurons and astrocytes must be generated during brain development. In spite of this, very little is known about the molecular events governing proliferation and differentiation in the astroglial lineage that culminate in the establishment of adequate numbers of astrocytes. In recent ...