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Medientyp:
E-Book;
Hochschulschrift
Titel:
Relevance of biomarkers for the diagnosis of the frailty syndrome
:
focus on parameters of muscle protein turnover, micronutrients and oxidative stress
Weitere Titel:
Übersetzung des Haupttitels: Die Bedeutung von Biomarkern für die Diagnose des Frailty-Syndroms : 3-Methylhistidine, Mikronährstoffe und oxidativer Stress im Fokus
Hochschulschrift:
Dissertation, Universität Potsdam, 2019
Anmerkungen:
kumulative Dissertation
Beschreibung:
Frailty and sarcopenia share some underlying characteristics like loss of muscle mass, low muscle strength, and low physical performance. Imaging parameters and functional examinations mainly assess frailty and sarcopenia criteria; however, these measures can have limitations in clinical settings. Therefore, finding suitable biomarkers that reflect a catabolic muscle state e.g. an elevated muscle protein turnover as suggested in frailty, are becoming more relevant concerning frailty diagnosis and risk assessment. 3-Methylhistidine (3-MH) and its ratios 3-MH-to-creatinine (3-MH/Crea) and 3 MH-to-estimated glomerular filtration rate (3-MH/eGFR) are under discussion as possible biomarkers for muscle protein turnover and might support the diagnosis of frailty. However, there is some skepticism about the reliability of 3-MH measures since confounders such as meat and fish intake might influence 3-MH plasma concentrations. Therefore, the influence of dietary habits and an intervention with white meat on plasma 3-MH was determined in young ...