Beschreibung:
Frontmatter -- Preface -- Contents -- Chapter 1 Analytical chemistry in biopharma -- Chapter 2 A brief overview of biological mass spectrometry: concepts and definitions -- Chapter 3 Characterization of covalent structure of protein therapeutics -- Chapter 4 Characterization of higher order structure and protein interactions -- Chapter 5 Biosimilars and comparability studies -- Chapter 6 Characterization of impurities in biopharmaceutical products -- Chapter 7 Quantitation of protein therapeutics in biological samples -- Chapter 8 Non-protein biopharmaceuticals and related macromolecular drugs -- Chapter 9 What is next? -- Index
Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state-of-the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress-related structural changes to their quantitation in pharmacokinetic studies