Beschreibung:
One major concern of today’s life is the increase of antimicrobial resistance and the rising num-ber of multi drug resistant bacterial species. There is an urgent need of identifying new antibi-otic drug targets since resistances threaten the repertoire of available antibiotics. Cyclic di-AMP (c-di-AMP) is the only known essential second messenger mainly found in Gram-positive bacteria of which several are known as human pathogens (Woodward et al. 2010; Luo Y and Helmann 2012; Mehne et al. 2013; Gundlach et al. 2015a; Commichau et al. 2017; Gundlach et al. 2017a; Gundlach et al. 2017b; Com...