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Medientyp:
E-Book;
Hochschulschrift
Titel:
Nachweis und isoformspezifische Funktion von HMGB1-Protein im osteoarthritischen Knorpel und chondrogenen Progenitorzellen
Paralleltitel:
Detection and isoform-specific function of high mobility group box protein 1 (HMGB1) in human osteoarthritic cartilage and chondrogenic progenitor cells.
Beschreibung:
Osteoarthritis (OA) is a common musculoskeletal disease in the elderly, characterized by painful aseptic inflammation, destruction of the joint surface and subchondral sclerosis. In late-stage OA, human articular cartilage harbors a unique progenitor cell population (CPCs) with stem cell characteristics such as multipotency and migratory activity. The aim of the present study was to analyze the HMGB1 distribution in OA cartilage and its effect on CPCs. HMGB1 protein is expressed by all eukaryotic cells and it is named for its rapid mobility on electrophoresis gels. HMGB1 was originally iden...