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Witt, Eric
[Verfasser:in]
;
Völker, Uwe
[Akademische:r Betreuer:in];
Sommer, Diana
[Akademische:r Betreuer:in];
Hammer, Elke
[Akademische:r Betreuer:in]
Universität Greifswald
The impact of cytokines, stress, and the cellular sex on the proteome of cardiac and vascular cell models
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- Medientyp: E-Book; Hochschulschrift
- Titel: The impact of cytokines, stress, and the cellular sex on the proteome of cardiac and vascular cell models
- Beteiligte: Witt, Eric [Verfasser:in]; Völker, Uwe [Akademische:r Betreuer:in]; Sommer, Diana [Akademische:r Betreuer:in]; Hammer, Elke [Akademische:r Betreuer:in]
- Körperschaft: Universität Greifswald
-
Erschienen:
Greifswald, 23.02.2020
- Umfang: 1 Online-Ressource (PDF-Datei: 148 Seiten, 4921 Kilobyte); Illustrationen (teilweise farbig), Diagramme (teilweise farbig)
- Sprache: Englisch
- Identifikator:
-
RVK-Notation:
VK 8560 : Allgemeines
-
Schlagwörter:
Herz
>
Blutgefäß
>
Cytokine
>
Stress
>
Zwilling
>
Proteom
>
Zellkultur
>
Massenspektrometrie
- Entstehung:
-
Hochschulschrift:
Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020
-
Anmerkungen:
Literaturverzeichnis: Seite 113-129
-
Beschreibung:
Herz, Massenspektrometrie, Molekularbiologie, Proteom, Zellkultur, Zwilling, Cell culture, Heart, Mass spectrometry, Molecular biology, Proteome, Twins
Cardiovascular diseases are the most common cause of death in industrial nations. The basis of these diseases is a dysfunction in the interaction between the cells the heart is composed of. The main types of cells making up the human heart are cardiomyocytes that build the myocardium and provide the contraction properties, endothelial cells that delimit the blood flowing through the inner chambers and coronary arteries from the myocardial tissue, and fibroblasts, which build the connective tissue. A common process in the development of cardiovascular diseases is the formation of fibrosis due to injury of the endothelium and subsequent infiltration of the cardiac tissue by immune cells, and inflammatory agents like cytokines. Cytokines exert different functions in cardiac cells. Tumor necrosis factor α (TNFα) is an inducer of apoptosis. Transforming growth factor ß (TGFß) is known for activation of proliferation. Other cytokines like C-X-C motif chemokine 11 (CXCL11), interleukin-6 (IL-6), or brain-derived neurotrophic factor (BDNF) have not yet been investigated or their impact on such cells is unknown. Eventually, however, fibrotic scar tissue arises from the transition from fibroblasts to myofibroblasts leading to a stiffening of the cardiac muscle and impaired pump function. In order to prevent the occurrence of these events the balance of proliferation, migration, and differentiation of cardiac cells needs to be controlled very delicately. The mechanisms controlling these ... - Zugangsstatus: Freier Zugang