Reich, Lena Alexa
[VerfasserIn]
;
Lotze, Martin
[AkademischeR BetreuerIn];
Rasch, Björn
[AkademischeR BetreuerIn]Universität Greifswald
Beeinflussung der kognitiven Leistung durch so-tDCS während des Nachtschlafs bei älteren gesunden Probanden: Explorative post hoc Analyse verschiedener Faktoren bezüglich der Ansprechbarkeit auf die elektrische Stimulation
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Medientyp:
E-Book;
Hochschulschrift
Titel:
Beeinflussung der kognitiven Leistung durch so-tDCS während des Nachtschlafs bei älteren gesunden Probanden: Explorative post hoc Analyse verschiedener Faktoren bezüglich der Ansprechbarkeit auf die elektrische Stimulation
Hochschulschrift:
Dissertation, Universitätsmedizin der Universität Greifswald, 2020
Anmerkungen:
Literaturverzeichnis: Seite 62-72
Mit deutscher und englischer Zusammenfassung
Beschreibung:
Nachtschlaf, so-tDCS
Introduction: Some studies in young subjects have shown an improvement of memory consolidation during early, nocturnal nonREM sleep after applying slow-oscillatory transcranial direct current stimulation (so-tDCS). Consolidation of declarative memories during sleep depends on neurophysiological events which are observed to undergo a change while aging. In this study we focused on the posthoc analysis that as a central question explored inter-individual differences in responsiveness to so-tDCSdue to the large variability demonstrated in previous studies. Methods: Ina randomized, single-blind crossover study so-tDCS (0.75 Hz) versus sham stimulation was applied over the frontal cortex of 22 healthy subjects in the age of 50 –80. Posthoc SO were used to devide subject group in Responder (increase of power in frontal SO following so-tDCS) and Nonresponder (no increase or decrease of power in frontal SO following so-tDCS) to explore inter-individual factors of responsiveness to stimulation correlating cognitive and anatomic parameters as well as sleep characteristic andsleep behavior. Therefore five stimulation blocks (five minutes each) followed by an 1-min stimulation-free intervals were applied and the impact of stimulation on performance of declarative, hippocampal-dependent memory task was assessed. Electroencephalographic activity was recorded throughout the night and effects of stimulation on brain activity such as spectral power within three frequency bands (slow ...