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Brandt, Julia [Verfasser:in]; Warnke, Katharina [Verfasser:in]; Jörgens, Silke [Verfasser:in]; Arolt, Volker [Verfasser:in]; Beer, Katja [Verfasser:in]; Domschke, Katharina [Verfasser:in]; Haverkamp, Wilhelm [Verfasser:in]; Kuhlmann, Stella L. [Verfasser:in]; Müller-Nordhorn, Jacqueline [Verfasser:in]; Rieckmann, Nina [Verfasser:in]; Schwarte, Kathrin [Verfasser:in]; Ströhle, Andreas [Verfasser:in]; Tschorn, Mira [Verfasser:in]; Waltenberger, Johannes [Verfasser:in]; Große, Laura [Verfasser:in]

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

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  • Medientyp: E-Book; Sonderdruck
  • Titel: Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study
  • Beteiligte: Brandt, Julia [Verfasser:in]; Warnke, Katharina [Verfasser:in]; Jörgens, Silke [Verfasser:in]; Arolt, Volker [Verfasser:in]; Beer, Katja [Verfasser:in]; Domschke, Katharina [Verfasser:in]; Haverkamp, Wilhelm [Verfasser:in]; Kuhlmann, Stella L. [Verfasser:in]; Müller-Nordhorn, Jacqueline [Verfasser:in]; Rieckmann, Nina [Verfasser:in]; Schwarte, Kathrin [Verfasser:in]; Ströhle, Andreas [Verfasser:in]; Tschorn, Mira [Verfasser:in]; Waltenberger, Johannes [Verfasser:in]; Große, Laura [Verfasser:in]
  • Erschienen: Wien [u.a.]: Springer Nature, 2020
  • Erschienen in: Journal of neural transmission ; 127 (2020), 1651–1662
  • Umfang: 1 Online-Ressource (12 Seiten); Diagramm
  • Sprache: Englisch
  • DOI: 10.1007/s00702-020-02243-6
  • Identifikator:
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract: Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients’ prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD
  • Zugangsstatus: Freier Zugang