• Medientyp: E-Book; Hochschulschrift
  • Titel: Kinetic analysis of mammalian translation initiation
  • Beteiligte: Yi, Sung-Hui [Verfasser:in]; Rodnina, Marina [Akademische:r Betreuer:in]; Adio, Sarah [Akademische:r Betreuer:in]; Bohnsack, Markus [Akademische:r Betreuer:in]; Tittmann, Kai [Akademische:r Betreuer:in]; Stark, Holger [Akademische:r Betreuer:in]; Urlaub, Henning [Akademische:r Betreuer:in]
  • Erschienen: Göttingen, 2021
  • Umfang: 1 Online-Ressource; Illustrationen, Diagramme
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Dissertation, Georg-August-Universität Göttingen, 2020
  • Anmerkungen:
  • Beschreibung: During translation initiation in mammalian cells, 80S ribosomes are assembled at the translation start site on mRNA via a cap-dependent scanning mechanism. The formation of the 80S initiation complex (IC) is essential for proper selection of the start codon and requires concerted action of at least 10 eukaryotic initiation factors (eIFs). This process can be divided into five stages: binding of eIFs to the 40S subunit to assemble the 43S pre-IC (PIC), mRNA recruitment to the 43S PIC, mRNA scanning, 48S IC formation upon start codon recognition, and finally, 80S IC formation after 60S subuni...
  • Zugangsstatus: Freier Zugang