> Detailanzeige

Murrieta-Coxca, José Martin [VerfasserIn]; Gutiérrez-Samudio, Ruby Nicole [VerfasserIn]; El-Shorafa, Heba [VerfasserIn]; Groten, Tanja [VerfasserIn]; Rodríguez-Martínez, Sandra [VerfasserIn]; Cancino-Diaz, Mario E. [VerfasserIn]; Cancino-Diaz, Juan C. [VerfasserIn]; Favaro, Rodolfo [VerfasserIn]; Markert, Udo R. [VerfasserIn]; Morales Prieto, Diana Maria [VerfasserIn]

Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells
  • Beteiligte: Murrieta-Coxca, José Martin [VerfasserIn]; Gutiérrez-Samudio, Ruby Nicole [VerfasserIn]; El-Shorafa, Heba [VerfasserIn]; Groten, Tanja [VerfasserIn]; Rodríguez-Martínez, Sandra [VerfasserIn]; Cancino-Diaz, Mario E. [VerfasserIn]; Cancino-Diaz, Juan C. [VerfasserIn]; Favaro, Rodolfo [VerfasserIn]; Markert, Udo R. [VerfasserIn]; Morales Prieto, Diana Maria [VerfasserIn]
  • Erschienen: 30 December 2020
  • Erschienen in: International journal of molecular sciences ; 22(2021,1) Artikel-Nummer 285, 17 Seiten
  • Sprache: Englisch
  • DOI: 10.3390/ijms22010285
  • ISSN: 1422-0067
  • Identifikator:
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract: IL-36 cytokines (the agonists IL-36α, IL-36β, IL-36γ, and the antagonist IL-36Ra) are expressed in the mouse uterus and associated with maternal immune response during pregnancy. Here, we characterize the expression of IL-36 members in human primary trophoblast cells (PTC) and trophoblastic cell lines (HTR-8/SVneo and JEG-3) and upon treatment with bacterial and viral components. Effects of recombinant IL-36 on the migration capacity of trophoblastic cells, their ability to interact with endothelial cells and the induction of angiogenic factors and miRNAs (angiomiRNAs) were examined. Constitutive protein expression of IL-36 (α, β, and γ) and their receptor (IL-36R) was found in all cell types. In PTC, transcripts for all IL-36 subtypes were found, whereas in trophoblastic cell lines only for IL36G and IL36RN. A synthetic analog of double-stranded RNA (poly I:C) and lipopolysaccharide (LPS) induced the expression of IL-36 members in a cell-specific and time-dependent manner. In HTR-8/SVneo cells, IL-36 cytokines increased cell migration and their capacity to interact with endothelial cells. VEGFA and PGF mRNA and protein, as well as the angiomiRNAs miR-146a-3p and miR-141-5p were upregulated as IL-36 response in PTC and HTR-8/SVneo cells. In conclusion, IL-36 cytokines are modulated by microbial components and regulate trophoblast migration and interaction with endothelial cells. Therefore, a fundamental role of these cytokines in the placentation process and in response to infections may be expected. Keywords: pregnancy; trophoblast; IL-36 cytokines; migration; angiogenesis; microRNAs
  • Zugangsstatus: Freier Zugang