Beschreibung:
Axo-glia interaction extend beyond myelination itself. Glial cells support axons with metabolites and trophic factors. In numerous disease models, primary glial mutations result in the disturbance of normal nerve conduction. In Charcot-Marie-Tooth disease type 1A (CMT1A), an overexpression of peripheral myelin protein 22 (PMP22) in Schwann cells (SC), the myelinating glial cells of the peripheral nervous system, results in severely reduced nerve conduction velocities and eventually loss of compound muscle action potentials (CMAP) in patients as well as in a rat model (Pmp22tg). Previous stu...