Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

Medientyp: E-Artikel
Titel: Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis
Beteiligte: Marquard, Simone [Verfasser:in]; Thomann, Stefan [Verfasser:in]; Weiler, Sofia Maria Elisabeth [Verfasser:in]; Bissinger, Michaela [Verfasser:in]; Lutz, Teresa [Verfasser:in]; Sticht, Carsten [Verfasser:in]; Tóth, Marcell [Verfasser:in]; Torre, Carolina de la [Verfasser:in]; Gretz, Norbert [Verfasser:in]; Straub, Beate Katharina [Verfasser:in]; Marquardt, Jens [Verfasser:in]; Schirmacher, Peter [Verfasser:in]; Breuhahn, Kai [Verfasser:in]
Erschienen: 23 October 2020
Erschienen in: Cell communication and signaling ; 18(2020), Artikel-ID 166, Seite 1-15
Sprache: Englisch
DOI: 10.1186/s12964-020-00634-6
Identifikator:

Schlagwörter: Hepatocellular carcinoma ; Hippo pathway ; Liver cancer ; Oncogene ; Transcriptional regulator
Entstehung:
Anmerkungen:
Beschreibung: Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tumor microenvironment is not well understood.
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