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Leung, Oscar M. [Verfasser:in]; Li, Jiatao [Verfasser:in]; Li, Xisheng [Verfasser:in]; Chan, Vicken W. [Verfasser:in]; Yang, Kevin Y. [Verfasser:in]; Ku, Manching [Verfasser:in]; Ji, Lu [Verfasser:in]; Sun, Hao [Verfasser:in]; Waldmann, Herman [Verfasser:in]; Tian, Xiao Yu [Verfasser:in]; Huang, Yu [Verfasser:in]; Lau, James [Verfasser:in]; Zhou, Bin [Verfasser:in]; Lui, Kathy O. [Verfasser:in]

Regulatory T cells promote apelin-mediated sprouting angiogenesis in Type 2 diabetes

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  • Medientyp: E-Book; Sonderdruck
  • Titel: Regulatory T cells promote apelin-mediated sprouting angiogenesis in Type 2 diabetes
  • Beteiligte: Leung, Oscar M. [Verfasser:in]; Li, Jiatao [Verfasser:in]; Li, Xisheng [Verfasser:in]; Chan, Vicken W. [Verfasser:in]; Yang, Kevin Y. [Verfasser:in]; Ku, Manching [Verfasser:in]; Ji, Lu [Verfasser:in]; Sun, Hao [Verfasser:in]; Waldmann, Herman [Verfasser:in]; Tian, Xiao Yu [Verfasser:in]; Huang, Yu [Verfasser:in]; Lau, James [Verfasser:in]; Zhou, Bin [Verfasser:in]; Lui, Kathy O. [Verfasser:in]
  • Erschienen: New York, NY: Elsevier BV, 2018
  • Erschienen in: Cell reports ; 24, 6 (2018), 1610-1626
  • Umfang: 1 Online-Ressource (18 Seiten); Illustrationen, Diagramme; Supplemental information (1 Zip-Datei: 2 PDF-Dateien)
  • Sprache: Englisch
  • DOI: 10.1016/j.celrep.2018.07.019
  • Identifikator:
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  • Beschreibung: Abstract: The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients’ vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human angiogenesis. We then blocked CD4+ T cell infiltration into the ischemic tissues of both Leprdb/db and diet-induced obese T2D mice. Genome-wide RNA sequencing shows an increased proliferative and angiogenic capability of diabetic ECs in ischemic tissues. Moreover, wire myography shows enhanced EC function and laser Doppler imaging reveals improved post-ischemic blood reperfusion. Mechanistically, functional revascularization after CD4 coreceptor blockade was mediated by Tregs. Genetic lineage tracing via Cdh5-CreER and Apln-CreER and coculture assays further illustrate that Tregs increased vascular density and induced de novo sprouting angiogenesis in a paracrine manner. Taken together, our results reveal that Th1 impaired while Tregs promoted functional post-ischemic revascularization in obesity and diabetes
  • Zugangsstatus: Freier Zugang