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Medientyp:
E-Book;
Hochschulschrift
Titel:
Aberrant CDK1 activity in s phase induces chromosomal instability by increasing mitotic microtubule polymerisation rates in colorectal cancer cells
Beschreibung:
Whole chromosomal instability (W-CIN), one of the major hallmarks of human cancer, is defined as the perpetual gain or loss of whole chromosomes during mitosis leading to the development of heterogeneous karyotypes. W-CIN is associated with tumourigenesis, tumour progression, therapy resistance, and poor prognosis. Therefore, it is of great interest to elucidate the molecular mechanisms underlying W-CIN in order to understand genome instability driven tumorigenesis and tumour progression. Recently, our lab has shown that W-CIN is triggered by increased microtubule polymerisation rates durin...