Beschreibung:
Renal cell carcinomia (RCC) is one of the ten most common and malignant tumor diseases worldwide. At current state, RCC represents 86% of all malignant kidney diseases. As medical research shows RCC is usually chemoresistant. Over the last decades the efflux transporters of the ATP- binding cassette (ABC)- superfamily have intensively been studied. It is proved that these proteins are related to the chemoresistance of cells. In renal cancer cells the influx transporters of the solute carrier (SLC) family are not well understood. SLC transporters are shown to be involved in absorption, distr...