Beschreibung:
The mitochondrial oxidative phosphorylation machinery is comprised by five individual complexes and arranged in supramolecular structures, so-called supercomplexes, as it is shown for complex I, III, IV and V. In yeast S. cerevisiae complex I is substituted by three singular NADH dehydrogenases and therefore lacks multimeric complex I. Thus, it displays a suitable model for investigating the dynamics within supercomplex formation of complex III and IV. Although some players could be identified so far, it is mostly unknown which factors contribute to forming these complexes (III2IV(1-2)). Be...