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Deschler, Sebastian
[VerfasserIn];
Kager, Juliane
[VerfasserIn];
Erber, Johanna
[VerfasserIn];
Fricke, Lisa
[VerfasserIn];
Koyumdzhieva, Plamena
[VerfasserIn];
Georgieva, Alexandra
[VerfasserIn];
Lahmer, Tobias
[VerfasserIn];
Wiessner, Johannes R.
[VerfasserIn];
Voit, Florian
[VerfasserIn];
Schneider, Jochen
[VerfasserIn];
Horstmann, Julia
[VerfasserIn];
Iakoubov, Roman
[VerfasserIn];
Treiber, Matthias
[VerfasserIn];
Winter, Christof Alexander
[VerfasserIn];
Ruland, Jürgen Maximilian
[VerfasserIn];
Busch, Dirk H.
[VerfasserIn];
Knolle, Percy A.
[VerfasserIn];
Protzer-Knolle, Ulrike
[VerfasserIn];
Spinner, Christoph Daniel
[VerfasserIn];
Schmid, Roland M.
[VerfasserIn];
Quante, Michael
[VerfasserIn];
Böttcher, Katrin
[VerfasserIn]
Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients
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- Medientyp: E-Book; Sonderdruck
- Titel: Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients
- Beteiligte: Deschler, Sebastian [VerfasserIn]; Kager, Juliane [VerfasserIn]; Erber, Johanna [VerfasserIn]; Fricke, Lisa [VerfasserIn]; Koyumdzhieva, Plamena [VerfasserIn]; Georgieva, Alexandra [VerfasserIn]; Lahmer, Tobias [VerfasserIn]; Wiessner, Johannes R. [VerfasserIn]; Voit, Florian [VerfasserIn]; Schneider, Jochen [VerfasserIn]; Horstmann, Julia [VerfasserIn]; Iakoubov, Roman [VerfasserIn]; Treiber, Matthias [VerfasserIn]; Winter, Christof Alexander [VerfasserIn]; Ruland, Jürgen Maximilian [VerfasserIn]; Busch, Dirk H. [VerfasserIn]; Knolle, Percy A. [VerfasserIn]; Protzer-Knolle, Ulrike [VerfasserIn]; Spinner, Christoph Daniel [VerfasserIn]; Schmid, Roland M. [VerfasserIn]; Quante, Michael [VerfasserIn]; Böttcher, Katrin [VerfasserIn]
- Erschienen: Basel: MDPI AG, 2021
- Erschienen in: Viruses ; 13, 2 (2021), 241
- Umfang: 1 Online-Ressource (18 Seiten); Diagramme; Supplementary material (1 PDF-Datei, 4 Seiten)
- Sprache: Englisch
- DOI: 10.3390/v13020241
- ISSN: 1999-4915
- Identifikator:
- Entstehung:
- Anmerkungen:
- Beschreibung: Abstract: Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry. Our data indicate that MAIT cells are highly activated in patients with COVID-19, irrespective of the course of disease, and express high levels of proinflammatory cytokines such as IL-17A and TNFα ex vivo. Of note, expression of the activation marker HLA-DR positively correlated with SAPS II score, a measure of disease severity. Upon MAIT cell-specific in vitro stimulation, MAIT cells however failed to upregulate expression of the cytokines IL-17A and TNFα, as well as cytolytic proteins, that is, granzyme B and perforin. Thus, our data point towards an altered cytokine expression profile alongside an impaired antibacterial and antiviral function of MAIT cells in COVID-19 and thereby contribute to the understanding of COVID-19 immunopathogenesis
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