Postsynaptic GABA B Rs inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons

Medientyp: E-Book; Sonderdruck

Titel: Postsynaptic GABA B Rs inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons

Beteiligte: Booker, Sam A. [Verfasser:in]; Loreth, Desirée [Verfasser:in]; Gee, Annabelle L. [Verfasser:in]; Watanabe, Masahiko [Verfasser:in]; Kind, Peter C. [Verfasser:in]; Wyllie, David J.A. [Verfasser:in]; Kulik, Akos [Verfasser:in]; Vida, Imre [Verfasser:in]

Erschienen: New York, NY: Elsevier BV, 2018

Umfang: 1 Online-Ressource (9 Seiten); Illustrationen, Diagramme; Supplemental information

Sprache: Englisch

DOI: 10.1016/j.celrep.2017.12.021

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Beschreibung: Abstract: Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes. Here, we show that, while the archetypal dendritic-inhibitory somatostatin-expressing INs (SOM-INs) possess high levels of GABABR on their somato-dendritic surface, they fail to produce significant postsynaptic inhibitory currents. Instead, GABABRs selectively inhibit dendritic CaV1.2 (L-type) Ca2+ channels on SOM-IN dendrites, leading to reduced calcium influx and loss of long-term potentiation at excitatory input synapses onto these INs. These data provide a mechanism by which GABABRs can contribute to disinhibition and control the efficacy of extrinsic inputs to hippocampal networks

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