Development and validation of retention models in supercritical fluid chromatography for impregnation process design

Medientyp: E-Artikel

Titel: Development and validation of retention models in supercritical fluid chromatography for impregnation process design

Beteiligte: Sun, Miaotian [Verfasser:in]; Ülker, Zeynep [Verfasser:in]; Chen, Zhixing [Verfasser:in]; Deeptanshu, Sivaraman [Verfasser:in]; Johannsen, Monika [Verfasser:in]; Erkey, Can [Verfasser:in]; Gurikov, Pavel [Verfasser:in]

Körperschaft: Technische Universität Hamburg ; Technische Universität Hamburg, Institute of Thermal Separation Processes ; Technische Universität Hamburg, Institute of Multiphase Flows ; Technische Universität Hamburg, Arbeitsgruppe Entwicklung und Modellierung Neuartiger Nanoporöser Materialien

Erschienen: 31 July 2021

Sprache: Englisch

DOI: 10.15480/882.3714; 10.3390/app11157106

Identifikator:

Schlagwörter: aerogels ; adsorption ; impregnation ; supercritical fluid chromatography ; retention model

Entstehung:

Anmerkungen: Sonstige Körperschaft: Technische Universität Hamburg
Sonstige Körperschaft: Technische Universität Hamburg, Institute of Thermal Separation Processes
Sonstige Körperschaft: Technische Universität Hamburg, Institute of Multiphase Flows
Sonstige Körperschaft: Technische Universität Hamburg, Arbeitsgruppe Entwicklung und Modellierung Neuartiger Nanoporöser Materialien

Beschreibung: The retention factor is the key quantity for the thermodynamic analysis of the retention mechanism in chromatographic experiments. In this work, we measure retention factors for moderately polar solutes on four silica-based porous matrices as stationary phases by supercritical fluid chromatography. Elution of the solutes is only possible with binary mixtures of supercritical carbon dioxide (sc-CO₂) and modifier (methanol) due to the low polarity of pure sc-CO₂. The addition of modifiers makes the retention mechanism more complex and masks interactions between solute and stationary phase. In this work, we develop and validate several retention models that allow the obtaining of retention factors in modifier-free sc-CO₂. Such models pave the way for quantifying adsorption interactions between polar solutes and non-swellable porous matrices in pure sc-CO₂ based on retention data obtained in sc-CO₂-modifier mixtures. The obtained information will thereby facilitate the understanding and design of impregnation processes, which are often performed in modifier-free conditions.

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