Elektrophysiologische Untersuchungen der synaptischen Plastizität in humanen Präparaten von Patientinnen und Patienten mit Temporallappenepilepsie

Medientyp: E-Book; Hochschulschrift

Titel: Elektrophysiologische Untersuchungen der synaptischen Plastizität in humanen Präparaten von Patientinnen und Patienten mit Temporallappenepilepsie

Beteiligte: Schröter, Sarah [VerfasserIn]; Brandner, Sebastian [AkademischeR BetreuerIn]; Maslarova, Anna [AkademischeR BetreuerIn]; Buchfelder, Michael [Sonstige Person, Familie und Körperschaft]; Brandner, Sebastian [Sonstige Person, Familie und Körperschaft]

Erschienen: Erlangen: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021

Umfang: 1 Online-Ressource

Sprache: Deutsch

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Schlagwörter: Hochschulschrift

Entstehung:

Hochschulschrift: Dissertation, Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2022

Anmerkungen:

Beschreibung: Objectives: Memory formation and learning is possible due to the dynamic reconstruction of synapses. This phenomenon is called synaptic plasticity and represents a unique skill of the brain. Indeed, without the ability to create new neural pathways and modify synapses, memory would not exist. However, the highly complex process of synaptic network modulation in the human brain is still not fully understood. Given the unique opportunity to obtain vital neuronal tissue samples from humans during surgical interventions for therapy-resistant temporal lobe epilepsy (TLE), research on synaptic plasticity has been expanded. However, with regard to data in human tissue, there are still significant gaps in the understanding of memory formation and learning in the human brain. Particularly interesting is the question whether and how degenerative processes affect synaptic plasticity and to what extent the mechanisms leading to synaptic plasticity can be improved and supported. This is highly relevant today as many neurological diseases manifest themselves in symptoms such as memory impairment. Recommendations for therapeutic strategies are rare since the degenerative changes have not yet been adequately studied. A deeper understanding of synaptic plasticity might possibly result in a clinically relevant implication for potential treatment options. The goal of this thesis was to contribute to a better understanding of synaptic plasticity in the human brain particularly in the temporal lobe. In addition, this thesis researches the influence of glucocorticoids and glucocorticoid receptors (GR) on synaptic plasticity. Design & Methods: One common way to study synaptic plasticity and to obtain a better understanding of possible influencing factors is the electrophysiological investigation of active neural networks. For this purpose, tissue was gained from patients suffering from therapy-resistant TLE and received a surgical therapy. Using the resected tissue samples, acute slices were prepared in which neuronal activity was ...

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