Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects ; Cancer bronchique non à petites cellules, immunité et microbiote : base d'étude de l'axe intestin-poumon-cancer du poumon chez l'Homme
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Medientyp:
E-Book
Titel:
Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects ; Cancer bronchique non à petites cellules, immunité et microbiote : base d'étude de l'axe intestin-poumon-cancer du poumon chez l'Homme
Erschienen:
[Erscheinungsort nicht ermittelbar]: HAL CCSD, 2019
Sprache:
Englisch
Entstehung:
Hochschulschrift:
Dissertation, HAL CCSD, 2019
Anmerkungen:
Beschreibung:
Lung cancer is the main cause of death by cancer worldwide. Despite the variety of available treatments, including surgery, chemotherapy, radiotherapy, and immune therapy, the average 5-year survival is 60%. One of the underlying reasons is a very high variability in patients' susceptibility to treatment, explained by genetic background and since recently – our microbiota. The term microbiota includes bacteria, archaea, fungi, viruses and protists that inhabit our organism. The studies in animal models show that the gut microbiota (focused on bacteria) has a crucial role in host's responsiveness to therapy through the stimulation of immune system. In this light, several communication axes" between the gut and distal tumour sites have started to develop, including the "gut-lung" axis. However, the resident microbiota in the lungs that could directly influence the tumour response and interact with the gut microbiota has been scarcely characterised. To enable further development of the idea of the "gut-lung-lung cancer" axis, we included 18 non-small cell lung cancer (NSCLC) patients eligible for surgery and analysed the microbiota from four different lung samples (non-malignant, peritumoural and tumour tissue and bronchoalveolar lavage fluid