Erschienen in:Int. J. Sci. Res. Environ. Sci. 2(9): 308-322 (2014)
Umfang:
1 Online-Ressource (15 p)
Sprache:
Englisch
DOI:
10.2139/ssrn.3856327
Identifikator:
Entstehung:
Anmerkungen:
Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments 2014 erstellt
Beschreibung:
Carbofuran-fed changes in body, liver and kidney weights as well as alterations in the histopathology of hepatic and renal tissues in the Swiss albino mice Mus musculaus L. were assessed. Twenty 7-10 days old male mice were divided equally into five groups viz. T0 (control), T1, T2, T3 and T4, which were allowed to feed on Carbofuran supplemented diets at doses of 0.0 (control), 0.5, 1.0, 1.5 and 2.0 mg/kg food. Compared to the decrease in body and kidney weights of the treated mice, Carbofuran-fed diets resulted in a significant gain in both body (P<0.004) and kidney weights (P<0.025) but decrease in liver weight (P<0.001) of the untreated mice. Carbofuran treatments, however, decreased both hepatosomatic and Reno somatic indices of the experimental mice. Histological microphotographs of the liver and kidney tissues of the control showed no abnormalities in structure, color, and appearance. While those of the treated mice showed remarkable changes that include hemosiderin in hepatocytes, epithelial and Kupffer cells, dilated sinusoids, hemorrhage and vacuolation, necrotic hepatocytes and congested central and portal veins, inflammatory cell infiltration and increased number of mononuclear cells in liver sections. In kidney sections, on the other hand, edema, congested or degenerated glomeruli, widened urinary spaces, dilated or vacuolated tubules, degenerated or eroded walls of Bowman’s capsules, hemorrhages and inflammatory cell infiltrations, hyalinized areas and increased numbers of podocytes and mesangial cells were notable characteristics. Relevance of these findings to the indiscriminate uses of this carbamate insecticide in agriculture and public health has been discussed