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Vierthaler, Marlene [Verfasser:in]; Sun, Qian [Verfasser:in]; Wang, Yiman [Verfasser:in]; Steinfass, Tamara [Verfasser:in]; Poelchen, Juliane [Verfasser:in]; Hielscher, Thomas [Verfasser:in]; Novak, Daniel [Verfasser:in]; Umansky, Viktor [Verfasser:in]; Utikal, Jochen [Verfasser:in]

ADCK2 knockdown affects the migration of melanoma cells via MYL6

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  • Medientyp: E-Artikel
  • Titel: ADCK2 knockdown affects the migration of melanoma cells via MYL6
  • Beteiligte: Vierthaler, Marlene [Verfasser:in]; Sun, Qian [Verfasser:in]; Wang, Yiman [Verfasser:in]; Steinfass, Tamara [Verfasser:in]; Poelchen, Juliane [Verfasser:in]; Hielscher, Thomas [Verfasser:in]; Novak, Daniel [Verfasser:in]; Umansky, Viktor [Verfasser:in]; Utikal, Jochen [Verfasser:in]
  • Erschienen: 20 February 2022
  • Erschienen in: Cancers ; 14(2022), 4, Artikel-ID 1071, Seite 1-18
  • Sprache: Englisch
  • DOI: 10.3390/cancers14041071
  • Identifikator:
  • Schlagwörter: ADCK2 ; cancer ; melanoma ; motility ; MYL6
  • Entstehung:
  • Anmerkungen: This article belongs to the Special Issue Epidemiology and Biological Features of Melanoma
  • Beschreibung: Background: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motility. In this study, we investigated the role of ADCK2 in melanoma. Methods: The effect of ADCK2 on melanoma cell motility was evaluated by a scratch assay and a transwell invasion assay upon siRNA-mediated knockdown or stable overexpression of ADCK2. Results: We found that high levels of intratumoral ADCK2 and MYL6 are associated with a higher survival rate in melanoma patients. Knocking down ADCK2 resulted in enhanced cell migration of melanoma cells. Moreover, ADCK2-knockdown cells adopted a more dedifferentiated phenotype. A gene expression array revealed that the expression of ADCK2 correlated with the expressions of MYL6 and RAB2A. Knocking down MYL6 in ADCK2-overexpressing cells could abrogate the effect of ADCK2 overexpression and thus confirm the functional connection between ADCK2 and MYL6. Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma.
  • Zugangsstatus: Freier Zugang