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González, Mario Alberto [Verfasser:in]; Barrera-Chacón, Rafael [Verfasser:in]; Peña, Fernando J. [Verfasser:in]; Fernández-Cotrina, Javier [Verfasser:in]; Robles, Nicolás R. [Verfasser:in]; Pérez-Merino, Eva M. [Verfasser:in]; Martín-Cano, Francisco E. [Verfasser:in]; Duque, Francisco J. [Verfasser:in]

Urinary Proteome of Dogs with Renal Disease Secondary to Visceral Leishmaniasis

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  • Medientyp: E-Book
  • Titel: Urinary Proteome of Dogs with Renal Disease Secondary to Visceral Leishmaniasis
  • Beteiligte: González, Mario Alberto [Verfasser:in]; Barrera-Chacón, Rafael [Verfasser:in]; Peña, Fernando J. [Verfasser:in]; Fernández-Cotrina, Javier [Verfasser:in]; Robles, Nicolás R. [Verfasser:in]; Pérez-Merino, Eva M. [Verfasser:in]; Martín-Cano, Francisco E. [Verfasser:in]; Duque, Francisco J. [Verfasser:in]
  • Erschienen: [S.l.]: SSRN, [2022]
  • Umfang: 1 Online-Ressource (44 p)
  • Sprache: Englisch
  • DOI: 10.2139/ssrn.4025959
  • Identifikator:
  • Entstehung:
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  • Beschreibung: Canine visceral leishmaniasis is frequently associated with the development of renal disease. Its pathogenesis is complex and not fully understood. For this reason, this study aimed to describe the urinary proteome of dogs with kidney disease secondary to leishmaniasis, and identify possible new biomarkers for renal disease in leishmaniasis. Urine samples were collected from 20 dogs, 5 from healthy dogs, and 15 from stages Leishvet III and IV. Urine samples were analyzed by UHPLC–MS/MS. The data are available via ProteomeXchange with identifier PXD029165. A total of 951 proteins were obtained. After bioinformatic analysis, 93 urinary proteins were altered in the study group. Enrichment analysis performed on these proteins showed an overrepresentation of the complement activation pathway, among others. Finally, 12 discriminant variables were found in dogs with renal disease secondary to leishmaniasis, highlighting C4a anaphylatoxin, apolipoprotein A-I, haptoglobin, leucine-rich alpha-2-glycoprotein 1, and beta-2-microglobulin . This study is the first to describe the urinary proteomics of dogs with renal disease caused by leishmaniasis. It provides new possible biomarkers for the diagnosis and monitoring of the disease and it shows the potential use of canines as a model for this type of renal disease
  • Zugangsstatus: Freier Zugang