Effect of the Losartan Potassium, Metformin Hydrochloride and Simvastatin on in Vitro Bioacessibility of Cu, Fe, Mn and Zn in Oats Flour from Brazil

Medientyp: E-Book

Titel: Effect of the Losartan Potassium, Metformin Hydrochloride and Simvastatin on in Vitro Bioacessibility of Cu, Fe, Mn and Zn in Oats Flour from Brazil

Beteiligte: de Carvalho, Wellington Correia [VerfasserIn]; de Sousa, Thaís Luz [VerfasserIn]; de Jesus, Ana Cláudia Lima [VerfasserIn]; Souza, Laís Araújo [VerfasserIn]; dos Santos, Luana Cardoso [VerfasserIn]; Simões da Silva, Saul Vislei [VerfasserIn]; Santos, Daniele Cristina Muniz Batist [VerfasserIn]; DE FREITAS SANTOS JUNIOR, ANIBAL [VerfasserIn]; Korn, Maria Graças Andrade [VerfasserIn]

Erschienen: [S.l.]: SSRN, [2022]

Umfang: 1 Online-Ressource (21 p)

Sprache: Englisch

DOI: 10.2139/ssrn.4011565

Identifikator:

Entstehung:

Anmerkungen:

Beschreibung: BackgroundThe simultaneous administration of drugs and food can compromise the bioaccessibility of both, resulting from possible interactions. The objective of this study was, for the first time in literature, to evaluate the influence of the use of losartan potassium, metformin hydrochloride and simvastatin on the in vitro bioaccessibility of micronutrientes (Cu, Fe, Mn and Zn) in oat flour from Bahia, Brazil.MethodsThe experimental procedure for the decomposition of the sample (oat flour and residue) was carried out in a digester block with a closed system. For the in vitro extraction of the bioaccessible fraction of oat flour (with and without medicines) the Unificated Bioaccessibility Method (UBM) was applied simulating the conditions of the gastrointestinal tract. To determine the total content (flour and residual fraction) and bioaccessible micronutrients, inductively coupled plasma optical emission spectrometry (ICP OES) was used.ResultsThe bioaccessible contents (µg g-1) without the addition of drugs were: Cu 5.86 ± 0.21; Fe 32.80 ± 1.32; Mn 87.90 ± 1.90; Zn 30.33 ± 2.05, with bioaccessibility ranging from 31.5 for Fe to 99% for Mn. The in vitro extraction method was validated by mass balance with recovery values from 89.78 for Cu to 101.94% for Mn. The ranges of bioaccessible contents (µg g-1) were: Cu (< 4.14), Fe (32.10 ± 0.20 – 54.10 ± 2.03), Mn (81.40 ± 0.93 – 93.22 ± 0.80) and Zn (< 10.80 – 29.11 ± 2.20).ConclusionThe results obtained for the estimation of the bioaccessibility of Cu, Fe, Mn and Zn in the matrix were equivalent or inferior, in the presence of most drugs, showing that interactions can occur between drugs and micronutrients. Therefore, losartan potassium, metformin hydrochloride and simvastatin can interfere on the bioaccessibility of micronutrients in oat flour, in patients who use these drugs

Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: