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Qiu, Zhigang [VerfasserIn]; Wang, Shang [VerfasserIn]; Zhao, Chen [VerfasserIn]; Xue, Bin [VerfasserIn]; Li, Chenyu [VerfasserIn]; Zhang, Xi [VerfasserIn]; Yang, Xiaobo [VerfasserIn]; Li, Yan [VerfasserIn]; Yang, Yanping [VerfasserIn]; Shen, Zhiqiang [VerfasserIn]; Wang, Jingfeng [VerfasserIn]

Nanoalumina Triggers the Antibiotic Persistence of Escherichia Coli Through Quorum Sensing Regulators Lrsf and Qseb

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  • Medientyp: E-Book
  • Titel: Nanoalumina Triggers the Antibiotic Persistence of Escherichia Coli Through Quorum Sensing Regulators Lrsf and Qseb
  • Beteiligte: Qiu, Zhigang [VerfasserIn]; Wang, Shang [VerfasserIn]; Zhao, Chen [VerfasserIn]; Xue, Bin [VerfasserIn]; Li, Chenyu [VerfasserIn]; Zhang, Xi [VerfasserIn]; Yang, Xiaobo [VerfasserIn]; Li, Yan [VerfasserIn]; Yang, Yanping [VerfasserIn]; Shen, Zhiqiang [VerfasserIn]; Wang, Jingfeng [VerfasserIn]
  • Erschienen: [S.l.]: SSRN, [2022]
  • Umfang: 1 Online-Ressource (57 p)
  • Sprache: Englisch
  • DOI: 10.2139/ssrn.4031547
  • Identifikator:
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Nanomaterials with significant bactericidal effects might provide novel strategies against bacteria in the post-antibiotic era. However, some bacteria can survive under nanomaterials exposure for unknown reasons, which challenges the safety of antibacterial nanomaterials. Here, we found that bacteria can improve persistence to escape killing by nanoalumina. Both reactive oxygen species and antitoxin-toxin system were involved in mechanisms of persisters formation induced by nanoalumina. The expression levels of persisters regulating genes including hipB , dksA , ygfA , tisB , tolC ,and rpoS , were significantly upregulated; however, the results of genes knockout confirmed that only hipB was associated with persisters formation caused by nanoalumina, suggesting that other mechanisms were included. We further identified 73 differentially expressed genes in transcriptome and analyzed them according to functional enrichment, signal pathways and interaction network. We finally selected out six candidate genes and validated five genes closely related to quorum sensing (QS) that were involved in persisters formation, and further validated that the coexpression of QS factors lrsF and qseB was regarded as a novel pathway of persisters formation induced by nanoalumina. Our data indicated that bacteria could improve persistence through QS mechanisms to avoid the killing of nanomaterials
  • Zugangsstatus: Freier Zugang