Geographical Approach Analysis of the Impact of Air Pollution on Newborn Metrics and Cord Blood DNA Damage in Mexico City

Medientyp: E-Book

Titel: Geographical Approach Analysis of the Impact of Air Pollution on Newborn Metrics and Cord Blood DNA Damage in Mexico City

Beteiligte: Maciel-Ruiz, Jorge [Verfasser:in]; Reynoso-Noverón, Nancy [Verfasser:in]; Rodríguez-Moreno, David A. [Verfasser:in]; Petrosyan, Pavel [Verfasser:in]; Limón-Pacheco, Jorge H. [Verfasser:in]; Nepomuceno-Hernández, Andrés E. [Verfasser:in]; Ayala-Yáñez, Rodrigo [Verfasser:in]; Robles-Morales, Rogelio [Verfasser:in]; Veloz-Martínez, María G. [Verfasser:in]; Ostrosky-Wegman, Patricia [Verfasser:in]; García Cuéllar, Claudia María [Verfasser:in]; Gonsebatt, Maria E. [Verfasser:in]

Erschienen: [S.l.]: SSRN, [2022]

Umfang: 1 Online-Ressource (31 p)

Sprache: Englisch

DOI: 10.2139/ssrn.4005936

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Anmerkungen: In: CHEM97106

Beschreibung: Studies worldwide have linked exposure to atmospheric pollutants with alterations in intrauterine development and increased levels of DNA damage. The Mexico City Metropolitan Area (MCMA) shows high levels of air pollution. We investigated the association of the levels of exposure to atmospheric pollutants during pregnancy in women residing in the MCMA with newborns’ birth weight (BW), length at birth (BL) and gestational age (GA) and DNA adduct levels in mother/newborn pairs through geographic modeling. The emissions data were calculated considering the emission source (area, point, mobile, and natural sources) in a 1 km x 1 km grid using two geographic buffers, 250 and 750 m around the residence. PM 10 area and point source emissions were negatively associated (p≤0.05) with BW, BL, and GA, while PM 2.5 point emissions were associated with a decrease in BL. Newborn DNA adduct levels were positively associated (p≤0.05) with PM 10 particulate matter emissions from area and point sources and with PM 2.5 and volatile organic compounds (VOC) from point sources in the 750-m buffer. PM and volatile and toxic compounds from mobile sources were significantly (p≤0.05) correlated with the cord blood/maternal blood adduct ratio (CMR), while no correlation between CMR and emissions from other sources was found. Emissions from natural or biogenic sources were associated with lower levels of DNA adducts in mothers (p≤0.01) and newborns (p≤0.05) and with improved characteristics of newborns (p≤0.05). It was determined that only PM exposure is related to levels of damage and neonatal characteristics through multivariate analysis by including other variables such as exposure to tobacco smoke, maternal occupation, maternal age, or parity. Our findings show the need to reduce the levels of particulate matter and further investigations of the possible benefits of urban green areas on pregnancy outcomes in the MCMA

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