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Zhong, Yu-Fei [Verfasser:in]; Bao, Guang-Ming [Verfasser:in]; Xia, Yi-Fan [Verfasser:in]; Li, Wei [Verfasser:in]; Tao, Ying-Qing [Verfasser:in]; Liu, Si-Yi [Verfasser:in]; Li, Si-Han [Verfasser:in]; Xiao, Wei [Verfasser:in]; Yuan, Hou-Qun [Verfasser:in]

Highly Selective and Sensitive Fluorescent Biosensor for the Detection of Serotonin and its Metabolite by Eu3+-Doped Metal-Organic Framework

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  • Medientyp: E-Book
  • Titel: Highly Selective and Sensitive Fluorescent Biosensor for the Detection of Serotonin and its Metabolite by Eu3+-Doped Metal-Organic Framework
  • Beteiligte: Zhong, Yu-Fei [Verfasser:in]; Bao, Guang-Ming [Verfasser:in]; Xia, Yi-Fan [Verfasser:in]; Li, Wei [Verfasser:in]; Tao, Ying-Qing [Verfasser:in]; Liu, Si-Yi [Verfasser:in]; Li, Si-Han [Verfasser:in]; Xiao, Wei [Verfasser:in]; Yuan, Hou-Qun [Verfasser:in]
  • Erschienen: [S.l.]: SSRN, [2022]
  • Umfang: 1 Online-Ressource (23 p)
  • Sprache: Englisch
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Monoamine neurotransmitters such as L-epinephrine (EPI), norepinephrine (NE), dopamine (DA), and serotonin (ST) are important biomarkers for neurological diseases. However, specific detection of a single monoamine neurotransmitter is challenging. In this work, a water-stable fluorescent biosensor, Eu 3+ -doped UiO-66 metal-organic framework ( EuUPDC ), is constructed for specific recognition of ST and its metabolite, 5-hydroxyindole-3-acetic acid (5-HI-3-AA). The detection limits of EuUPDC for ST and 5-HI-3-AA are 0.013 μM and 0.15 μM, respectively. The LOD value for ST is 10-fold improvement compared to the reported fluorescent sensors. Importantly, the biosensor specifically recognizes ST at very low concentrations in the presence of co-existing monoamine neurotransmitters. Furthermore, the EuUPDC biosensor is successfully applied for the determination of ST and 5-HI-3-AA in human serum and urine with good recoveries. Finally, a EuUPDC -embedded test strip is fabricated and portable smartphone-assisted RGB color values are effectively integrated with a lowest detectable value of 0.6 μM for ST and 6.7 μM for 5-HI-3-AA. The designed biosensor EuUPDC has great potential for the quantitative determination of ST and 5-HI-3-AA, and applicable for early diagnosis of neurological diseases
  • Zugangsstatus: Freier Zugang