Beschreibung:
Over the last decade, Cryo Electron Microscopy (cryo-EM) has emerged as a powerful and reliable technique to determine the three-dimensional (3D) structure of large macro-molecular assemblies at near atomic resolution. Tens of thousands of two-dimensional (2D) noisy images from copies of a macromolecule are captured at different unknown orientations to characterize the 3D volume of biological complexes. The reconstruction problem is typically formulated as a nonlinear, non-convex optimization task and multi-modality causes many of the conventional reconstruction techniques that work based o...