Beschreibung:
When an action potential arrives at the axon terminal, it causes a local and transient increase in the Ca2+ concentration that starts a cascade of molecular interactions eventually leading to the fusion of synaptic vesicles with the plasma membrane. The key proteins in this process – syntaxin-1A, SNAP25 and synaptobrevin 2 – assemble into a SNARE complex that directly drives the membrane fusion. The interaction of the SNARE proteins and mechanism by which this interaction mediates membrane fusion is intensively investigated. Despite numerous studies, the answers to the core questions regard...