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Koch, Vitali
[Verfasser:in];
Grünewald, Leon David
[Verfasser:in];
Albrecht, Moritz H.
[Verfasser:in];
Eichler, Katrin
[Verfasser:in];
Gruber-Rouh, Tatjana
[Verfasser:in];
Yel, Ibrahim
[Verfasser:in];
Alizadeh, Leona S.
[Verfasser:in];
Mahmoudi, Scherwin
[Verfasser:in];
Scholtz, Jan-Erik
[Verfasser:in];
Martin, Simon S.
[Verfasser:in];
Lenga, Lukas
[Verfasser:in];
Vogl, Thomas J.
[Verfasser:in];
Nour-Eldin, Nour-Eldin A.
[Verfasser:in];
Bienenfeld, Florian
[Verfasser:in];
Hammerstingl, Renate
[Verfasser:in];
Graf, Christiana
[Verfasser:in];
Sommer, Christof-Matthias
[Verfasser:in];
Hardt, Stefan
[Verfasser:in];
Mazziotti, Silvio
[Verfasser:in];
Ascenti, Giorgio
[Verfasser:in];
Versace, Giovanni Antonio
[Verfasser:in];
D'Angelo, Tommaso
[Verfasser:in];
Booz, Christian
[Verfasser:in]
Lung opacity and coronary artery calcium score
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- Medientyp: E-Artikel
- Titel: Lung opacity and coronary artery calcium score : a combined tool for risk stratification and outcome prediction in COVID-19 patients
- Beteiligte: Koch, Vitali [Verfasser:in]; Grünewald, Leon David [Verfasser:in]; Albrecht, Moritz H. [Verfasser:in]; Eichler, Katrin [Verfasser:in]; Gruber-Rouh, Tatjana [Verfasser:in]; Yel, Ibrahim [Verfasser:in]; Alizadeh, Leona S. [Verfasser:in]; Mahmoudi, Scherwin [Verfasser:in]; Scholtz, Jan-Erik [Verfasser:in]; Martin, Simon S. [Verfasser:in]; Lenga, Lukas [Verfasser:in]; Vogl, Thomas J. [Verfasser:in]; Nour-Eldin, Nour-Eldin A. [Verfasser:in]; Bienenfeld, Florian [Verfasser:in]; Hammerstingl, Renate [Verfasser:in]; Graf, Christiana [Verfasser:in]; Sommer, Christof-Matthias [Verfasser:in]; Hardt, Stefan [Verfasser:in]; Mazziotti, Silvio [Verfasser:in]; Ascenti, Giorgio [Verfasser:in]; Versace, Giovanni Antonio [Verfasser:in]; D'Angelo, Tommaso [Verfasser:in]; Booz, Christian [Verfasser:in]
-
Erschienen:
June 2022
- Erschienen in: Academic radiology ; 29(2022), 6 vom: Juni, Seite 861-870
- Sprache: Englisch
- DOI: 10.1016/j.acra.2022.02.019
- Identifikator:
- Schlagwörter: CAC-DRS Score ; Computed Tomography ; Coronary Heart Disease ; Coronary Plaque Burden ; SARS-CoV-2 Pneumonia
- Entstehung:
-
Anmerkungen:
Online veröffenticht: 28. Februar 2022
- Beschreibung: Purpose - To assess and correlate pulmonary involvement and outcome of SARS-CoV-2 pneumonia with the degree of coronary plaque burden based on the CAC-DRS classification (Coronary Artery Calcium Data and Reporting System). - Methods - This retrospective study included 142 patients with confirmed SARS-CoV-2 pneumonia (58 ± 16 years; 57 women) who underwent non-contrast CT between January 2020 and August 2021 and were followed up for 129 ± 72 days. One experienced blinded radiologist analyzed CT series for the presence and extent of calcified plaque burden according to the visual and quantitative HU-based CAC-DRS Score. Pulmonary involvement was automatically evaluated with a dedicated software prototype by another two experienced radiologists and expressed as Opacity Score. - Results - CAC-DRS Scores derived from visual and quantitative image evaluation correlated well with the Opacity Score (r=0.81, 95% CI 0.76-0.86, and r=0.83, 95% CI 0.77-0.89, respectively; p<0.0001) with higher correlation in severe than in mild stage SARS-CoV-2 pneumonia (p<0.0001). Combined, CAC-DRS and Opacity Scores revealed great potential to discriminate fatal outcomes from a mild course of disease (AUC 0.938, 95% CI 0.89-0.97), and the need for intensive care treatment (AUC 0.801, 95% CI 0.77-0.83). Visual and quantitative CAC-DRS Scores provided independent prognostic information on all-cause mortality (p=0.0016 and p<0.0001, respectively), both in univariate and multivariate analysis. - Conclusions - Coronary plaque burden is strongly correlated to pulmonary involvement, adverse outcome, and death due to respiratory failure in patients with SARS-CoV-2 pneumonia, offering great potential to identify individuals at high risk.
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