Beschreibung:
The non-invasive characterization of brain myelin has essential applications in basic neuroscience and the clinical management of white matter brain diseases and other inflammatory and neurodegenerative diseases. Magnetic resonance imaging (MRI) provides a variety of image contrasts that change in relation to myelin alterations. However, it is not clear how these potential MRI biomarkers of myelin reflect the underlying tissue structure at the meso- and microscale. Due to physical and technical limitations, the spatial resolution of MRI is poor in comparison to the size of tissue constituen...