Anmerkungen:
Tag der Verteidigung: 25.10.2022
Zusammenfassungen in deutscher Sprache
Beschreibung:
Low molecular weight organic dyes emitting in the near infrared (NIR) (650- 1000 nm) represent optimal contrast agents in fluorescence image guided surgery of tumors as the low energy photons are not absorbed neither scattered by endogenous chromophores. To date, the main limitations that the existing chromophore possess, are low water solubility, photobleaching and tendency to aggregation due to their extended conjugated systems. We worked on the modification of the perylene monoimide scaffold to develop water soluble, highly photostable NIR “always ON probes” for in vivo NIR Angiography and sentinel lymph node mapping. Additionally, we are investigating pH activatable ON-OFF Si-Rhodamine probes that can be conjugated with antibodies as targeting moieties toward overexpressed receptors in cancer cells to detect diseased tissues and their boundaries with high signal to noise ratio.