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Piazena, Helmut [VerfasserIn]; Müller, Werner [VerfasserIn]; Pendl, Wolfgang [VerfasserIn]; Ah, Sereina von [VerfasserIn]; Cap, Veronika [VerfasserIn]; Hug, Petra Julia [VerfasserIn]; Sidler, Xaver [VerfasserIn]; Pluschke, Gerd [VerfasserIn]; Vaupel, Peter [VerfasserIn]

Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens

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  • Medientyp: E-Book
  • Titel: Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens
  • Beteiligte: Piazena, Helmut [VerfasserIn]; Müller, Werner [VerfasserIn]; Pendl, Wolfgang [VerfasserIn]; Ah, Sereina von [VerfasserIn]; Cap, Veronika [VerfasserIn]; Hug, Petra Julia [VerfasserIn]; Sidler, Xaver [VerfasserIn]; Pluschke, Gerd [VerfasserIn]; Vaupel, Peter [VerfasserIn]
  • Erschienen: Freiburg: Universität, 2019
  • Umfang: 1 Online-Ressource
  • Sprache: Englisch
  • DOI: 10.1080/02656736.2019.1655594
  • Identifikator:
  • Schlagwörter: Wärmetherapie
  • Entstehung:
  • Anmerkungen: International journal of hyperthermia and thermal therapies. - 36, 1 (2019) , 938-952, ISSN: 1464-5157
  • Beschreibung: Abstract: Purpose: The temporal and spatial formation of the temperature field and its changes during/upon water-filtered infrared-A (wIRA)-irradiation in porcine skin and subcutis were investigated in vivo in order to get a detailed physical basis for thermotherapy of superficial tumors and infections caused by thermosensitive microbial pathogens (e.g., Mycobacterium ulcerans causing Buruli ulcer).<br><br>Methods: Local wIRA-hyperthermia was performed in 11 anesthetized piglets using 85.0 mW cm−2, 103.2 mW cm−2 and 126.5 mW cm−2, respectively. Invasive temperature measurements were carried out simultaneously in 1-min intervals using eight fiber-optical probes at different tissue depths between 2 and 20 mm, and by an IR thermometer at the skin surface.<br><br>Results: Tissue temperature distribution depended on incident irradiance, exposure time, tissue depths and individual ‘physiologies’ of the animals. Temperature maxima were found at depths between 4 and 7 mm, exceeding skin surface temperatures by about 1–2 K. Tissue temperatures above 37 °C, necessary to eradicate M. ulcerans at depths <20 mm, were reached reliably.<br><br>Conclusions: wIRA-hyperthermia may be considered as a novel therapeutic option for treatment of local skin infections caused by thermosensitive pathogens (e.g., in Buruli ulcer). To ensure temperatures required for heat treatment of superficial tumors deeper than 4 mm, the incident irradiance needed can be controlled either by (a) invasive temperature measurements or (b) control of skin surface temperature and considering possible temperature increases up to 1–2 K in underlying tissue
  • Zugangsstatus: Freier Zugang