Beeinflusst der knockdown des membranständigen Östrogenrezeptors GPER (GPR30) die anti-invasive Wirksamkeit selektiver Östrogenrezeptor beta (ERb)-Agonisten?
Beschreibung:
The aim of the present work was to investigate to what extent suppression of GPER1 affects viability and invasiveness of TNBC cells. In addition, it was of interest to determine whether suppression of GPER1 affects the efficacy of selective ERβ agonists. In malignant breast cancer cells, estrogen receptor beta (ERb) has anti-proliferative and anti-invasive effects. Accordingly, a significantly better survival of patients with ERb positive triple-negative breast cancer (TNBC) compared to ERb negative TNBC can be achieved. G protein-coupled estrogen receptor 1 (GPER1) is often over-expressed ...