Lopes, Tiago Jose da Silva
[VerfasserIn];
Luganskaja, Tatyana
[VerfasserIn];
Spasić Vujić, Maja
[VerfasserIn];
Hentze, Matthias W.
[VerfasserIn];
Muckenthaler, Martina
[VerfasserIn];
Schümann, Klaus
[VerfasserIn];
Reich, Jens G.
[VerfasserIn]
Beschreibung:
Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation in different cell types is intertwined with a global hormonal signalling structure. Iron deficiency as well as excess of iron are frequent and serious human disorders. They can affect every cell, but also the organism as a whole.