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Jin, Fukang [Verfasser:in]; Zhu, Lei [Verfasser:in]; Shao, Jingbo [Verfasser:in]; Yakoub, Mina [Verfasser:in]; Schmitt, Lukas [Verfasser:in]; Reißfelder, Christoph [Verfasser:in]; Loges, Sonja [Verfasser:in]; Benner, Axel [Verfasser:in]; Schölch, Sebastian [Verfasser:in]

Circulating tumour cells in patients with lung cancer universally indicate poor prognosis

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  • Medientyp: E-Artikel
  • Titel: Circulating tumour cells in patients with lung cancer universally indicate poor prognosis : review
  • Beteiligte: Jin, Fukang [Verfasser:in]; Zhu, Lei [Verfasser:in]; Shao, Jingbo [Verfasser:in]; Yakoub, Mina [Verfasser:in]; Schmitt, Lukas [Verfasser:in]; Reißfelder, Christoph [Verfasser:in]; Loges, Sonja [Verfasser:in]; Benner, Axel [Verfasser:in]; Schölch, Sebastian [Verfasser:in]
  • Erschienen: December 14, 2022
  • Erschienen in: European respiratory review ; 31(2022), 166, Artikel-ID 220151, Seite 1-14
  • Sprache: Englisch
  • DOI: 10.1183/16000617.0151-2022
  • Identifikator:
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  • Beschreibung: Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration. - Methods: We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values. - Results: 27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids. - Conclusion: CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs. - Tweetable abstract ERSpublications - click to tweetThis meta-analysis demonstrates that the prognostic value of epithelial CTCs is greater than that of mesenchymal CTCs in lung cancer. CTCs indicate poor prognosis in all subtypes of lung cancer; this effect increases with CTC detection thresholds. https://bit.ly/3dhlY0C
  • Zugangsstatus: Freier Zugang