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Medientyp:
E-Book;
Hochschulschrift
Titel:
Extracellular vesicles as the potential mediators of psychosocial stress contribution to osteoporosis
:
a narrative review
Weitere Titel:
Übersetzung des Haupttitels: Extrazelluläre Vesikel als potenzielle Mediatoren für den Beitrag von psychosozialem Stress zur Osteoporose: ein narrativer Überblick
Hochschulschrift:
Dissertation, Universität Potsdam, 2023
Anmerkungen:
Beschreibung:
Background: The characteristics of osteoporosis are decreased bone mass and destruction towards the microarchitecture of bone tissue, which raises the risk of fracture. Psychosocialstress and osteoporosis are linked by sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and other endocrine factors. Psychosocial stress causes a series of effects on the organism, and this long-term depletion at the cellular level is considered to be mitochondrial allostatic load, including mitochondrial dysfunction and oxidative stress. Extracellular vesicles (EVs) are involved in the mitochondrial allostatic load process and may as biomarkers in this setting. As critical participants during cell-to-cell communications, EVs serve as transport vehicles for nucleic acid and proteins, alter the phenotypic and functional characteristics of their target cells, and promote cell-to-cell contact. And hence, they play a significant role in the diagnosis and therapy of many diseases, such as osteoporosis. Aim: This narrative review attempts to ...