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Hehlmann, Rüdiger
[VerfasserIn];
Voskanyan, Astghik
[VerfasserIn];
Lauseker, Michael
[VerfasserIn];
Pfirrmann, Markus
[VerfasserIn];
Kalmanti, Lida
[VerfasserIn];
Rinaldetti, Sébastien
[VerfasserIn];
Kohlbrenner, Katharina
[VerfasserIn];
Haferlach, Claudia
[VerfasserIn];
Schlegelberger, Brigitte
[VerfasserIn];
Fabarius, Alice
[VerfasserIn];
Seifarth, Wolfgang
[VerfasserIn];
Spiess, Birgit
[VerfasserIn];
Wuchter, Patrick
[VerfasserIn];
Krause, Stefan
[VerfasserIn];
Kolb, Hans-Jochem
[VerfasserIn];
Neubauer, Andreas
[VerfasserIn];
Hossfeld, Dieter K.
[VerfasserIn];
Nerl, Christoph
[VerfasserIn];
Gratwohl, Alois
[VerfasserIn];
Baerlocher, Gabriela M.
[VerfasserIn];
Burchert, Andreas
[VerfasserIn];
Brümmendorf, Tim Henrik
[VerfasserIn];
Hasford, Jörg
[VerfasserIn];
Hochhaus, Andreas
[VerfasserIn];
[...]
High-risk additional chromosomal abnormalities at low blast counts herald death by CML
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- Medientyp: E-Artikel
- Titel: High-risk additional chromosomal abnormalities at low blast counts herald death by CML
- Beteiligte: Hehlmann, Rüdiger [VerfasserIn]; Voskanyan, Astghik [VerfasserIn]; Lauseker, Michael [VerfasserIn]; Pfirrmann, Markus [VerfasserIn]; Kalmanti, Lida [VerfasserIn]; Rinaldetti, Sébastien [VerfasserIn]; Kohlbrenner, Katharina [VerfasserIn]; Haferlach, Claudia [VerfasserIn]; Schlegelberger, Brigitte [VerfasserIn]; Fabarius, Alice [VerfasserIn]; Seifarth, Wolfgang [VerfasserIn]; Spiess, Birgit [VerfasserIn]; Wuchter, Patrick [VerfasserIn]; Krause, Stefan [VerfasserIn]; Kolb, Hans-Jochem [VerfasserIn]; Neubauer, Andreas [VerfasserIn]; Hossfeld, Dieter K. [VerfasserIn]; Nerl, Christoph [VerfasserIn]; Gratwohl, Alois [VerfasserIn]; Baerlocher, Gabriela M. [VerfasserIn]; Burchert, Andreas [VerfasserIn]; Brümmendorf, Tim Henrik [VerfasserIn]; Hasford, Jörg [VerfasserIn]; Hochhaus, Andreas [VerfasserIn]; Saußele, Susanne [VerfasserIn]; Baccarani, Michele [VerfasserIn]
- Erschienen: 07 May 2020
- Erschienen in: Leukemia ; 34(2020), 8, Seite 2074-2086
- Sprache: Englisch
- DOI: 10.1038/s41375-020-0826-9
- ISSN: 1476-5551
- Identifikator:
- Schlagwörter: Genetics research ; Translational research
- Entstehung:
- Anmerkungen:
- Beschreibung: Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory.
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