Mitrega, Jakub
[VerfasserIn]
;
Alves, Frauke
[AkademischeR BetreuerIn];
Bogeski, Ivan
[AkademischeR BetreuerIn]
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
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Medientyp:
E-Book;
Hochschulschrift
Titel:
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
Beschreibung:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the microenvironmental acidosis and p53 mutation. The aim of my project was to determine whether adaptation to acidity and acute extracellular pH (pHe) changes together with the p53 mutation affected PDAC related processes. Here I applied in vitro cell based assays and in vivo PDAC mouse models that were performed with Panc02 murine cells either expressing wild type p53 gene (lately ...