High temporal resolution dual-source photon-counting CT for coronary artery disease: initial multicenter clinical experience

Medientyp: E-Artikel

Titel: High temporal resolution dual-source photon-counting CT for coronary artery disease : initial multicenter clinical experience

Beteiligte: Soschynski, Martin [Verfasser:in]; Hagen, Florian [Verfasser:in]; Baumann, Stefan [Verfasser:in]; Hagar, Muhammad Taha [Verfasser:in]; Weiss, Jakob [Verfasser:in]; Krauss, Tobias [Verfasser:in]; Schlett, Christopher L. [Verfasser:in]; von zur Mühlen, Constantin [Verfasser:in]; Bamberg, Fabian [Verfasser:in]; Nikolaou, Konstantin [Verfasser:in]; Greulich, Simon [Verfasser:in]; Froelich, Matthias F. [Verfasser:in]; Riffel, Philipp [Verfasser:in]; Overhoff, Daniel [Verfasser:in]; Papavassiliu, Theano [Verfasser:in]; Schönberg, Stefan [Verfasser:in]; Faby, Sebastian [Verfasser:in]; Ulzheimer, Stefan [Verfasser:in]; Ayx, Isabelle [Verfasser:in]; Krumm, Patrick [Verfasser:in]

Erschienen: 11 October 2022

Sprache: Englisch

DOI: 10.3390/jcm11206003

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Schlagwörter: cardiac ; coronary ; CT ; photon counting ; spectral imaging

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Beschreibung: The aim of this paper is to evaluate the diagnostic image quality of spectral dual-source photon-counting detector coronary computed tomography angiography (PCD-CCTA) for coronary artery disease in a multicenter study. The image quality (IQ), assessability, contrast-to-noise ratio (CNR), Agatston score, and radiation exposure were measured. Stenoses were quantified and compared with invasive coronary angiography, if available. A total of 92 subjects (65% male, age 58 ± 14 years) were analyzed. The prevalence of significant coronary artery disease (CAD) (stenosis ≥ 50%) was 17% of all patients, the range of the Agatston score was 0-2965 (interquartile range (IQR) 0-135). The IQ was very good (one, IQR one-two), the CNR was very high (20 ± 10), and 5% of the segments were rated non-diagnostic. The IQ and assessability were higher in proximal coronary segments (p < 0.001). Agatston scores up to 600 did not significantly affect the assessability of the coronary segments (p = 0.3). Heart rate influenced assessability only at a high-pitch mode (p = 0.009). For the invasive coronary angiography (ICA) subgroup (n = nine), the diagnostic performance for CAD per segment was high (sensitivity 92%, specificity 96%), although the limited number of patients who underwent both diagnostic modalities limits the generalization of this finding at this stage. PCD-CCTA provides good image quality for low and moderate levels of coronary calcifications.

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