Hochschulschrift:
Dissertation, Universitätsmedizin der Universität Greifswald, 2023
Anmerkungen:
Literaturverzeichnis: Seite 46-49
Publikation in englischer Sprache
Beschreibung:
Cardiorespiratory fitness, peak oxygen uptake, physical inactivity, right ventricular geometry and function, right ventricular volumes, Kardiorespiratorische Leistungsfähigkeit, Rechtsventrikuläre Geometrie und Funktion, Kardiologie
Lower cardiorespiratory fitness (CRF) is associated with an increased risk for cardiovascular disease. However, very little information is available about the association between lower CRF and right ventricular (RV) remodeling. We investigated the relationship between CRF and RV structure and function in a large, aging, and largely sedentary adult population–based cohort. We used cross-sectional data of 2844 subjects (1486 women; median age, 51 years; interquartile range, 40–62 years) from the population-based cohort SHIP (Study of Health in Pomerania) with echocardiography,of which 941 also had cardiac magnetic resonance imaging. We analyzed the associations of peak oxygen uptake with RV parameters determined by both imaging techniques using multivariable-adjusted linear regression models. In echocardiography, a 1 L/min lower peak oxygen uptake was associated with a 1.18 mm(95% CI, 0.66–1.71; P<0.001) smaller RV end-diastolic diameter and a 1.41 mm (95% CI, 0.90–1.92; P<0.001) narrower RV end-diastolic outflow tract diameter. Similarly, using cardiac magnetic resonance imaging measurements, a 1 L/min lower peak oxygen uptake was associated with a 23.5 mL (95% CI, 18.7–28.4; P<0.001) smaller RV end-diastolic volume, a 13.0 mL (95% CI, 9.81–16.2; P<0.001) lower RV end-systolicvolume, and a 10.7 mL/beat (95% CI, 8.10–13.3; P<0.001) lower RV stroke volume. Our results indicate a significant association between CRF and RV remodeling. Lower CRF was associated with smaller RV ...