Rapp, Gregor Christof
[VerfasserIn]
;
Zeisberg, Michael
[AkademischeR BetreuerIn];
Neeße, Albrecht
[AkademischeR BetreuerIn];
Schön, Margarete
[AkademischeR BetreuerIn]
Untersuchung der pharmakologischen Modulation von ARNT-Homodimeren auf die Renoprotektion
= The pharmacological effect of ARNT homodimers on renoprotection
Beschreibung:
Chronic kidney disease is marked by progressive fibrosis and consecutive loss of function – the availability of specific therapies is limited. The bHLH-PAS transcription factor ARNT is able to form homodimeric complexes and to induce the expression of the renoprotective ALK3 in the tubular epithelium by binding to the ALK3 promoter. Pharmacologically, ARNT expression can be induced by a non-immunosuppressive dose of the pharmaceutical FK506 (low-dose) or by the small molecule GPI-1046. In the research literature, the protein phosphatase inhibitor okadaic acid is described as an inducer of A...